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Table 1 Summary of some SV-LAAOs and the tumor cell lines in which they were tested

From: Snake venom L-amino acid oxidases: an overview on their antitumor effects

Snake species LAAO Tumor cell lines Methodology References
Agkistrodon acutus ACTX-6 A549 MTT [23]
  ACTX-8 HeLa MTT, DNA fragmentation [57]
    Activation of caspases 3 and 9  
Agkistrodon contortrix laticinctus ACL LAO HL-60 DNA fragmentation [14]
Agkistrodon halys   L1210 DNA fragmentation [32]
   MOLT-4   
   HL-60   
Agkistrodon halys pallas   A549 DNA fragmentation [59]
Bothrops atrox BatroxLAAO HL-60 MTT [13, 27]
   PC12 Annexin V  
   B16F10 Activation of caspases  
   Jurkat   
Bothrops moojeni BmooLAAO-I HL-60 and EAT MTT and DNA fragmentation [60]
Bothrops pirajai BpirLAAO-I S180 MTT [20, 26]
    DNA fragmentation  
    HFS  
    Activation of caspases 3, 8 and 9  
   SKBR3   
   HL-60   
   HL-60.Bcr-Abl   
   EAT   
Bungarus fasciatus BF-LAAO A549   [49]
Calloselasma rhodostoma CR-LAAO Jurkat   [34]
Crotalus atrox Apoxin-I HL-60 DNA fragmentation [33, 54]
   A2780   
   HUVEC   
   KN-3   
Eristocophis macmahoni LNV-LAO MM6 DNA fragmentation [53]
Ophiophagus hannah   SNU-1 MTT [25, 61]
   B16F10 DNA fragmentation  
   MCF-7 Activation of caspases  
   A549   
Vipera berus berus   HeLa and K562 DNA fragmentation [55]