Snake venom L-amino acid oxidases: an overview on their antitumor effects

Table 1 Summary of some SV-LAAOs and the tumor cell lines in which they were tested

Snake species	LAAO	Tumor cell lines	Methodology	References
Agkistrodon acutus	ACTX-6	A549	MTT	[23]
	ACTX-8	HeLa	MTT, DNA fragmentation	[57]
			Activation of caspases 3 and 9
Agkistrodon contortrix laticinctus	ACL LAO	HL-60	DNA fragmentation	[14]
Agkistrodon halys		L1210	DNA fragmentation	[32]
		MOLT-4
		HL-60
Agkistrodon halys pallas		A549	DNA fragmentation	[59]
Bothrops atrox	BatroxLAAO	HL-60	MTT	[13, 27]
		PC12	Annexin V
		B16F10	Activation of caspases
		Jurkat
Bothrops moojeni	BmooLAAO-I	HL-60 and EAT	MTT and DNA fragmentation	[60]
Bothrops pirajai	BpirLAAO-I	S180	MTT	[20, 26]
			DNA fragmentation
			HFS
			Activation of caspases 3, 8 and 9
		SKBR3
		HL-60
		HL-60.Bcr-Abl
		EAT
Bungarus fasciatus	BF-LAAO	A549		[49]
Calloselasma rhodostoma	CR-LAAO	Jurkat		[34]
Crotalus atrox	Apoxin-I	HL-60	DNA fragmentation	[33, 54]
		A2780
		HUVEC
		KN-3
Eristocophis macmahoni	LNV-LAO	MM6	DNA fragmentation	[53]
Ophiophagus hannah		SNU-1	MTT	[25, 61]
		B16F10	DNA fragmentation
		MCF-7	Activation of caspases
		A549
Vipera berus berus		HeLa and K562	DNA fragmentation	[55]

ISSN: 1678-9199