Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva

Table 3 Examples of compounds from tick saliva

Compounds	Examples	Species	Molecular Mass (kDa)^a	Mechanism of Action	References
Enzyme Inhibitors	Amblyomin-X^b	Amblyomma cajennense	15.0	Factor Xa Inhibition/induction of apoptosis in tumor cells	134–136
	Savignin	Ornithodoros savignyi	14.1	Thrombin inhibitor	137–138
	Ixolaris	Ixodes scapularis	18.4	Tissue factor pathway inhibitor	139–140
	Variegin	Amblyomma variegatum	3.6	Thrombin inhibitor	145
Neurotoxin	HT-1 (Holocyclotoxins)	Ixodes holocyclus	7.8	Unclear	114, 146–148
Enzyme	Phospholipase A₂	Amblyomma americanum	55.7 ± 1.3	Hydrolysis of membrane phospholipids	158–159
Proteins	Hebraein	Amblyomma hebraeum	11.0	Unclear	163
	Ixosin	Ixodes sinensis	8.8	Unclear	165
	ISAMP	Ixodes scapularis	5.3	Unclear	167

ISSN: 1678-9199