Fig. 1

Effects of angiotensin-converting enzyme (ACE) inhibitors on morphology of the seminiferous epithelium of the mouse testis. Seminiferous tubules of the right testis of control animals treated with saline solution (C) and the left testis of mice treated with captopril (CAP), (inv)BPP-10c [(inv)10c], BPP-10c (10c), BPP-11e (11e) or BPP-AP (AP). Normal structure of tubules [C, CAP, (inv)10c, and 11e], germ cells in the lumen oftubules (10c, black arrow), degenerative tubule (10c and AP, red arrow), ruptures in the epithelium (10c, arrowheads), absence of round spermatids in stage V of the seminiferous epithelium cycle (10c, asterisk), round spermatids in the adluminal compartment (AP, double asterisk) and tubules with few germ cells, green arrow). Staining: Mallory’s Trichrome [C, CAP, (inv)10c and 10c] and PAS-Hematoxylin (11e and AP)