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Fig. 1 | Journal of Venomous Animals and Toxins including Tropical Diseases

Fig. 1

From: Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

Fig. 1

Effect of BmK I and BmK IT2 on DRG-type sodium channels. a Representative sodium currents under control conditions (top), after application of 400 nM BmK I (middle) and after application of 400 nM BmK I and 400 nM BmK IT2 to BmK I group (bottom), shown at intervals of 10 mV. b Representative sodium currents under control conditions (top), after application of 400 nM BmK IT2 (middle), and after application of 400 nM BmK I and 400 nM BmK IT2 to BmK IT2 group (bottom), shown at intervals of 10 mV. Representative sodium currents under control conditions, and after application of BSA (panel). c The I-V relationship of the VGSCs on ND7-23 cells in the absence (n = 6), presence of 400 nM BmK I (n = 5) and in presence of 400 nM BmK I and 400 BmK IT2 (n = 5). d The I-V relationship of the VGSCs on ND7-23 cells in the absence (n = 6), presence of 400nM BmK IT2 (n = 5) and in presence of 400 nM BmK I and 400 BmK IT2 (n = 5). *p < 0.05

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