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Table 1 Parameters for voltage dependence of steady-state activation and steady-state inactivation of the DRG-type sodium channels

From: Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

  Steady-state activation Steady-state inactivation  
  V1/2-a Ka V1/2-i Ki n
Control −30.0 ± 1.22 6.90 ± 0.54 −71.9 ± 0.90 6.97 ± 0.66 6
BmK I −42.0 ± 1.31* 7.05 ± 0.52 −75.6 ± 1.07 10.25 ± 0.64 5
BmK I-mix −48.6 ± 1.40** 3.29 ± 0.49* −76.8 ± 0.62 9.26 ± 0.33 5
Control −25.7 ± 1.81 4.27 ± 0.59 −69.2 ± 1.12 7.78 ± 0.67 6
BmK IT2 −38.1 ± 0.98* 4.48 ± 0.38 −72.2 ± 0.86 7.91 ± 0.36 5
BmK IT2-mix −30.1 ± 1.74 5.81 ± 0.73 −71.6 ± 1.06 9.84 ± 0.56 5
  1. *p < 0.05, **p < 0.01, significant difference to control (one-way ANOVA, Tukey test)
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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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