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Table 1 Parameters for voltage dependence of steady-state activation and steady-state inactivation of the DRG-type sodium channels

From: Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

 

Steady-state activation

Steady-state inactivation

 
 

V1/2-a

Ka

V1/2-i

Ki

n

Control

−30.0 ± 1.22

6.90 ± 0.54

−71.9 ± 0.90

6.97 ± 0.66

6

BmK I

−42.0 ± 1.31*

7.05 ± 0.52

−75.6 ± 1.07

10.25 ± 0.64

5

BmK I-mix

−48.6 ± 1.40**

3.29 ± 0.49*

−76.8 ± 0.62

9.26 ± 0.33

5

Control

−25.7 ± 1.81

4.27 ± 0.59

−69.2 ± 1.12

7.78 ± 0.67

6

BmK IT2

−38.1 ± 0.98*

4.48 ± 0.38

−72.2 ± 0.86

7.91 ± 0.36

5

BmK IT2-mix

−30.1 ± 1.74

5.81 ± 0.73

−71.6 ± 1.06

9.84 ± 0.56

5

  1. *p < 0.05, **p < 0.01, significant difference to control (one-way ANOVA, Tukey test)