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Table 1 Antileishmanial and mammalian cytotoxicity of whole venom and melittin

From: Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response

IC50 (μg.mL−1) (95 % CI)
  L. (L.) infantum Cytotoxicity (macrophages)
promastigotes amastigotes
Crude venom 87.0 (76.91 to 99.22) n.d. 27.59 (20.63 to 36.90)
Melittin 28.29 (23.97 to 33.39) 1.40 (1.21 to 1.63) 5.73 (5.08 to 6.44)
Miltefosine 6.69 (6.29 to 7.11) 6.87 (4.71 to 10.01) 49.72 (39.85 to 63.98)
  1. IC50: 50 % inhibitory concentration; 95 % CI: 95 % confidence interval; n.d.: not determined