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Table 1 Antileishmanial and mammalian cytotoxicity of whole venom and melittin

From: Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response

IC50 (μg.mL−1) (95 % CI)

 

L. (L.) infantum

Cytotoxicity (macrophages)

promastigotes

amastigotes

Crude venom

87.0 (76.91 to 99.22)

n.d.

27.59 (20.63 to 36.90)

Melittin

28.29 (23.97 to 33.39)

1.40 (1.21 to 1.63)

5.73 (5.08 to 6.44)

Miltefosine

6.69 (6.29 to 7.11)

6.87 (4.71 to 10.01)

49.72 (39.85 to 63.98)

  1. IC50: 50 % inhibitory concentration; 95 % CI: 95 % confidence interval; n.d.: not determined
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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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