In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Table 1 Characteristics of conopressins. Their amino acid sequences, respective species, target, clinical potential and references are indicated

Peptide	Amino acid sequence	Species	Target	Clinical potential	Source
Lys-conopressin-G	CFIRNCPKG^a	C. geographus	vasopressin R	cardiovascular/mood	[8, 9]
Arg-conopressin-S	CIIRNCPRG^a	C. striatus	V_1bR, OTR > V_1aR		[8]
γ-Conopressin-vil	CLIQDCPγG^a	C. villepinii	?		[13]
Conopressin-T	CYIQNCLRV^a	C. tulipa	V_1aR, OTR		[17]
Conopressin-Tx	CFIRNCOP	C. textile	?		[68]

^aN-terminal amidation; γ: gamma-carboxyglutamate; O: hydoxyproline; OTR: oxytocin-receptor; V_1aR: vascular vasopressin receptor, V_1bR: pituitary vasopressin receptor

ISSN: 1678-9199