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Table 14 Overview of the different families of disulfide-poor conopeptides discussed in this review. The different conopeptide families, a representative peptide and amino acid sequence of this peptide, respective Conus species, targets and, when applicable, clinical applications are indicated

From: In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Family Peptide representative Sequence Conus species Target Clinical applications
Conopressin Lys-conopressin-G CFIRNCPKGa C. geographus Vasopressin receptor Cardiovascular/mood
Contryphan Contryphan-R GCOWEPWCa C. radiatus VGPC, VGCC  
ConoCAP ConoCAP-a PFCNSFGCYNa C. villipinii ?  
ConoGAY ConoGAY-AusB GAYFDGFDVPCVPRRDDC C. australis ?  
Conantokin Con-G GEγγLQγNQγLIRγKSNa C. geographus NMDA receptor Pain/epilepsy
Contulakin Cont-G ZSEEGGSNAT#KKPYIL C. geographus Neurotensin Receptor Pain
Conorfamides Conorfamide-Sr1 GPMGWVPVFYRFa C. spurius RFamide receptor?  
Conophan Conophan Gld-V AOANSVWS C. gladiator ?  
Conomaps Conp-Vt AFVKGSAQRVAHGYa C. vitelinus ?[Excitatory peptide]  
Conomarphin Conomarphin DWEYHAHPKONSFWT C. marmoreus ?  
Conolysin Conolysin-Mt2 FHPSLWVLIPQYIQLIRKILKSa C. mustelinus Cellular membranes  
Cono-NPY Cono-NPY TVSDPPARPAVFHSREELMNYVRELNRYFAIVGRPRYa C. betulinus ?  
Hormone-like conopeptides Elevenin
PH-4
RRIDCKVFVFAPICRGVAA
IGFPGFSTPPR
C. victoriae ?  
  1. aN-terminal amidation; W: \( D \) -tryptophan; γ = Gla: γ-carboxyglutamic acid; Z = pE: pyroglutamaat; T#: Gal-GalNAc-Thr; V: \( D \) -Valine; F: \( D \) -Phe