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Table 14 Overview of the different families of disulfide-poor conopeptides discussed in this review. The different conopeptide families, a representative peptide and amino acid sequence of this peptide, respective Conus species, targets and, when applicable, clinical applications are indicated

From: In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Family

Peptide representative

Sequence

Conus species

Target

Clinical applications

Conopressin

Lys-conopressin-G

CFIRNCPKGa

C. geographus

Vasopressin receptor

Cardiovascular/mood

Contryphan

Contryphan-R

GCOWEPWCa

C. radiatus

VGPC, VGCC

 

ConoCAP

ConoCAP-a

PFCNSFGCYNa

C. villipinii

?

 

ConoGAY

ConoGAY-AusB

GAYFDGFDVPCVPRRDDC

C. australis

?

 

Conantokin

Con-G

GEγγLQγNQγLIRγKSNa

C. geographus

NMDA receptor

Pain/epilepsy

Contulakin

Cont-G

ZSEEGGSNAT#KKPYIL

C. geographus

Neurotensin Receptor

Pain

Conorfamides

Conorfamide-Sr1

GPMGWVPVFYRFa

C. spurius

RFamide receptor?

 

Conophan

Conophan Gld-V

AOANSVWS

C. gladiator

?

 

Conomaps

Conp-Vt

AFVKGSAQRVAHGYa

C. vitelinus

?[Excitatory peptide]

 

Conomarphin

Conomarphin

DWEYHAHPKONSFWT

C. marmoreus

?

 

Conolysin

Conolysin-Mt2

FHPSLWVLIPQYIQLIRKILKSa

C. mustelinus

Cellular membranes

 

Cono-NPY

Cono-NPY

TVSDPPARPAVFHSREELMNYVRELNRYFAIVGRPRYa

C. betulinus

?

 

Hormone-like conopeptides

Elevenin

PH-4

RRIDCKVFVFAPICRGVAA

IGFPGFSTPPR

C. victoriae

?

 
  1. aN-terminal amidation; W: \( D \) -tryptophan; γ = Gla: γ-carboxyglutamic acid; Z = pE: pyroglutamaat; T#: Gal-GalNAc-Thr; V: \( D \) -Valine; F: \( D \) -Phe