In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Table 5 Characteristics of conantokins. Their amino acid sequences, respective species, target, clinical potential and references are indicated

Peptide	Amino acid sequence	Species	Target	Clinical potential	Source
Conantokin-G	GEyyLQyNQyLIRyKSN^a	C. geographus	NR2B > NR2C, NR2D	pain/epilepsy	[28, 77]
Con-T	GEyyYQKMLyNLRyAEVKKNA^a	C. tulipa	NR2B, NR2A		[29]
Con-R	GEyyVAKMAAyLARyNIAKGCKVNCYP^a	C. radiatus	NR2B, NR2A		[35]
Con-L	GEyyVAKMAAyLARyDAVN^a	C. lynceus	?		[78]
Con-Ca2	GYγγRγIAγTVRγLEEA	C. caracteristicus	?		[79]
Con-Gm	GAKyRNNAyAVRyRLEEI	C. gloriamaris	?		[79]
Con-Qu	GYγγRγVAγTVRγLDAA	C. quercinus	?		[79]
Con-Oc	GEγγRKAMAγLEAKKAQγALKA	C. orchroleucus	?		[79]
Con-Pr1	GEDγYAγGIRγYQLIHGKI	C. parius	NR2B, NR2D		[80]
Con-Pr2	DEOγYAγAIRγYQLLKYGKI	C. parius	NR2B < NR2D		[80]
Con-Pr3	GEOγVAKWAγGLRγKAASN^a	C. parius	NR2B, NR2D		[80]
Con-E	GEγγHSKYQγCLRγIRVNNVQQγC	C. ermineus	?		[77]
Con-P	GEγγHSKYQγCLRγIRVNKVQQγC	C. purpurascens	NR2B, NR2A		[77]
Con-Br	GDγγYSKFIγRERγAGRLDLSKFP	C. sulcatus (brettinghami)	NR2B, NR2D, NR2A < NR2C		[81]

ISSN: 1678-9199