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Table 5 Characteristics of conantokins. Their amino acid sequences, respective species, target, clinical potential and references are indicated

From: In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Peptide Amino acid sequence Species Target Clinical potential Source
Conantokin-G GEyyLQyNQyLIRyKSNa C. geographus NR2B > NR2C, NR2D pain/epilepsy [28, 77]
Con-T GEyyYQKMLyNLRyAEVKKNAa C. tulipa NR2B, NR2A   [29]
Con-R GEyyVAKMAAyLARyNIAKGCKVNCYPa C. radiatus NR2B, NR2A   [35]
Con-L GEyyVAKMAAyLARyDAVNa C. lynceus ?   [78]
Con-Ca2 GYγγRγIAγTVRγLEEA C. caracteristicus ?   [79]
Con-Gm GAKyRNNAyAVRyRLEEI C. gloriamaris ?   [79]
Con-Qu GYγγRγVAγTVRγLDAA C. quercinus ?   [79]
Con-Oc GEγγRKAMAγLEAKKAQγALKA C. orchroleucus ?   [79]
Con-Pr1 GEDγYAγGIRγYQLIHGKI C. parius NR2B, NR2D   [80]
Con-Pr2 DEOγYAγAIRγYQLLKYGKI C. parius NR2B < NR2D   [80]
Con-Pr3 GEOγVAKWAγGLRγKAASNa C. parius NR2B, NR2D   [80]
Con-E GEγγHSKYQγCLRγIRVNNVQQγC C. ermineus ?   [77]
Con-P GEγγHSKYQγCLRγIRVNKVQQγC C. purpurascens NR2B, NR2A   [77]
Con-Br GDγγYSKFIγRERγAGRLDLSKFP C. sulcatus (brettinghami) NR2B, NR2D, NR2A < NR2C   [81]
  1. aN-terminal amidation; Gla: γ-carboxyglutamic acid; NR2: NMDA receptor