Table 5 Characteristics of conantokins. Their amino acid sequences, respective species, target, clinical potential and references are indicated

Conantokin-G

GEyyLQyNQyLIRyKSN^a

C. geographus

NR2B > NR2C, NR2D

pain/epilepsy

[28, 77]

Con-T

GEyyYQKMLyNLRyAEVKKNA^a

C. tulipa

NR2B, NR2A

[29]

Con-R

GEyyVAKMAAyLARyNIAKGCKVNCYP^a

C. radiatus

NR2B, NR2A

[35]

Con-L

GEyyVAKMAAyLARyDAVN^a

C. lynceus

?

[78]

Con-Ca2

GYγγRγIAγTVRγLEEA

C. caracteristicus

?

[79]

Con-Gm

GAKyRNNAyAVRyRLEEI

C. gloriamaris

?

[79]

Con-Qu

GYγγRγVAγTVRγLDAA

C. quercinus

?

[79]

Con-Oc

GEγγRKAMAγLEAKKAQγALKA

C. orchroleucus

?

[79]

Con-Pr1

GEDγYAγGIRγYQLIHGKI

C. parius

NR2B, NR2D

[80]

Con-Pr2

DEOγYAγAIRγYQLLKYGKI

C. parius

NR2B < NR2D

[80]

Con-Pr3

GEOγVAKWAγGLRγKAASN^a

C. parius

NR2B, NR2D

[80]

Con-E

GEγγHSKYQγCLRγIRVNNVQQγC

C. ermineus

?

[77]

Con-P

GEγγHSKYQγCLRγIRVNKVQQγC

C. purpurascens

NR2B, NR2A

[77]

Con-Br

GDγγYSKFIγRERγAGRLDLSKFP

C. sulcatus (brettinghami)

NR2B, NR2D, NR2A < NR2C

[81]