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Table 1 IC50 values of Aah venom and cisplatin in panel of cell lines NCI-H358, MCF7, HeLa, Hep-2, and MRC5

From: Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line

Treatment

Unit

IC50

  

NCI-H358a

MCF-7b

HeLac

Hep-2d

MRC5e

Aah venom

μg/mL

369.20 ± 1.33

458 ± 1.39

>500

>500

>500

Cisplatin

μM

11.2 ± 1.3

5.2 ± 1.6

6.31 ± 2.59

20 ± 1.8

9.3 ± 0.6

  1. Cells were treated with Aah venom or positive control (cisplatin) at varying concentrations for 24 h and cell viability was determined by MTT assay. IC50 is the concentration of compound that inhibits cell growth by 50 % and values represent mean ± SD of three independent experiments
  2. aNCI-H358: human lung adenocarcinoma cell line; bMCF7: human breast cancer cell line; cHeLa: human cervix adenocarcinoma; dHep-2: human laryngeal carcinoma cell line; eMRC5: normal human lung fibroblast
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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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