Antiviral activity of animal venom peptides and related compounds

Table 1 Scorpion peptides and derivatives with antiviral activity

Scorpion	Peptide name	Virus	EC₅₀	Reference
Lychas mucronatus	Mucroporin-M1	MeV	7.15 μg/mL (3.52 μM)	[39]
		SARS-CoV	14.46 μg/mL (7.12 μM)	[39]
		H5N1	2.10 μg/mL (1.03 μM)	[39]
		HBV	–	[40]
		HIV-1	–	[38]
Heterometrus petersii	Hp1090	HCV	7.62 μg/mL (5.0 μM)	[41]
	Hp1036	HSV-1	0.43 ± 0.09 μM	[42]
	Hp1239	HSV-1	0.41 ± 0.06 μM	[42]
Mesobuthus martensii	Kn2-7	HIV-1	2.76 μg/mL (1.65 μM)	[38]
Mesobuthus martensii	Bmkn2	HIV-1	–	[38]
Chaerilus tryznai	Ctry2459	HCV	1.84 μg/mL	[43]
	Ctry2459-H2	HCV	1.08 μg/mL	[43]
	Ctry2459-H3	HCV	0.85 μg/mL	[43]

EC ₅₀ peptide concentration required to reduce virus infection by 50%, HIV-1 human immunodeficiency virus type 1, MeV measles virus, HBV hepatitis B virus, HCV hepatitis C virus, SARS-CoV severe acute respiratory syndrome/coronavirus, H5N1 influenza virus, HSV-1 herpes simplex virus type 1. Adapted from Hmed et al. [8]

ISSN: 1678-9199