Fig. 1

Central antinociception induced by intracerebroventricular administration of PnPP-19 in mice. PnPP-19 (0.25, 0.5 and 1 μg) was administered 5 min prior measurement in the tail-flick test. Each line represents the mean ± SEM for four mice per group. *Significant difference compared to the Saline-injected group (ANOVA + Bonferroni test, p < 0.05). Saline (0.5% of Evans Blue)