Fig. 4

Potentiation of PnPP-19-induced antinociception by a bestatin, b MAFP or c VDM11. The bestatin (Bes; 20 μg), MAFP (0.2 μg) or VDM11 (4 μg) was administered 1 min prior to PnPP-19 (0.5 μg) injection. These drugs administered alone did not induce any effect. Each line represents the mean ± SEM for four mice per group. #Significant difference compared to the Sal + PnPP-19-injected group (ANOVA + Bonferroni’ test; p <0.05). Sal: saline (0.5% of Evans Blue)