Fig. 1
From: Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2
Effect of native and recombinant bothropstoxin I injection on the pain threshold and paw volume. a Effect of the native-BthTx intraplantar injection on the pain threshold and b on paw volume, at different doses. c Effect of recombinant BthTx-I intraplantar injection on the pain threshold and d on paw volume, at different doses. e Comparison between native and recombinant BthTx-I hyperalgesic and f edematogenic effects. The pain threshold of the animals was determined in rat hind paw before at different times after the intraplantar injection of PBS (control group) or toxins. Sensitivity to pain was measured as the threshold response to pressure and expressed as g. The edema was determined by an increase in the volume in the right hind paw of rats compared with the control contralateral paw. The paw volume was obtained pletsmografically. Each point represents the mean ± SEM of six animals. *Significantly different from mean values before venom injection and #different from BthTx-I-recombinant (BthTx-I rec) (p < 0.05)