Fig. 2
From: Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2
Effect of BthTx-I R118A (Arg118 → Ala) mutagenesis on rat pain threshold and paw volume. Decrease in a threshold response and b paw volume were determined in rat hind paw before and 2, 4, 6 and 24 h after the intraplantar injection of PBS (control group) or R118A, or recombinant BthTx-I. The paw volume was obtained pletsmografically. Sensitivity to pain was measured as the threshold response to pressure and expressed as g. The paw volume was obtained pletsmografically. Each point represents the mean ± SEM of six animals. *Significantly different from mean values before venom injection and #different from BthTx-I-recombinant (BthTx-I rec) (p < 0.05)