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Fig. 3 | Journal of Venomous Animals and Toxins including Tropical Diseases

Fig. 3

From: Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2

Fig. 3

Effect of BthTx-I K115A and K116A (Lys115 → Ala and Lys116 → Ala) mutagenesis on rat pain threshold and paw volume. Decrease in a threshold response and b paw volume were determined in rat hind paw before and 2, 4, 6 and 24 h after the intraplantar injection of PBS (control group) or R115A, or R116A, or recombinant BthTx-I. Sensitivity to pain was measured as the threshold response to pressure and expressed as g. The paw volume was obtained pletsmografically. Each point represents the mean ± SEM of six animals. *Significantly different from mean values before venom injection (p < 0.05)

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