Fig. 4
From: Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2
Effect of BthTx-I K122A (Lys122 → Ala) mutagenesis on rat pain threshold and paw volume. Decrease in a threshold response and b paw volume were determined in rat hind paw before and 2, 4, 6 and 24 h after the intraplantar injection of PBS (control group) or R122A, or recombinant BthTx-I. Sensitivity to pain was measured as the threshold response to pressure and expressed as g. The paw volume was obtained pletsmografically. Each point represents the mean ± SEM of six animals. *Significantly different from mean values before venom injection (p < 0.05)