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Table 1 Antitrypanosomal activity of ergosterol and cytotoxicity against mammalian cells

From: Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Compound

IC50 (μg/mL)

95% CI

trypomastigote

IC50 (μg/mL)

95% CI

amastigote

CC50 (μg/mL) 95% CI

macrophages

Selectivity index

Hemolytic activity (SD)

Ergosterol

51.3 (46.0–57.0)

>100

> 200

> 3.9

7.03% (±11.6)

Benznidazole

4.4 (3.7–5.1)

1.9 (1.2–2.3)

> 200

> 45.0

nd

  1. IC50: 50% effective concentration; CC50: 50% cytotoxic concentration; 95% CI: 95% confidence interval; SI: selectivity index calculated as (SI = CC50 mammalian cell/IC50 trypomastigotes); nd: not determined