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Table 1 Antitrypanosomal activity of ergosterol and cytotoxicity against mammalian cells

From: Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Compound IC50 (μg/mL)
95% CI
trypomastigote
IC50 (μg/mL)
95% CI
amastigote
CC50 (μg/mL) 95% CI
macrophages
Selectivity index Hemolytic activity (SD)
Ergosterol 51.3 (46.0–57.0) >100 > 200 > 3.9 7.03% (±11.6)
Benznidazole 4.4 (3.7–5.1) 1.9 (1.2–2.3) > 200 > 45.0 nd
  1. IC50: 50% effective concentration; CC50: 50% cytotoxic concentration; 95% CI: 95% confidence interval; SI: selectivity index calculated as (SI = CC50 mammalian cell/IC50 trypomastigotes); nd: not determined