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Fig. 1 | Journal of Venomous Animals and Toxins including Tropical Diseases

Fig. 1

From: It is time for top-down venomics

Fig. 1

Graphical representation of generic bottom-up (left panel) and top-down (right panel) venomics experiments. On the left panel, venom proteins are reduced, alkylated, enzymatically digested, and submitted to LC-MS/MS for peptide identification; toxins are inferred resulting in more protein possibilities than the original number of toxiforms (inference problem). On the right panel, venom is pre-fractionated before LC-MS/MS resulting in the identification and characterization of all toxiforms present in the initial sample

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