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Table 1 Full sequence of ponericin W5 (P82427) and its fragments. The full peptide corresponding to ponericin W5 and its fragments were identified in the venom of N. villosa. Isoforms of the full peptide and its fragments were also identified

From: Peptidomic investigation of Neoponera villosa venom by high-resolution mass spectrometry: seasonal and nesting habitat variations

Sequence Condition Mw (Da) Peptide processing/Mutations
FWGALIKGAAKLIPSVVGLFKKKQ Ponericin W5 2598.57
FWGALIKGAAKLIPSVVGLFKKKQ Nv1; Nv2; Nv3; Nv4 2598.57
FWGALIKGAAKLIPSVVGLFKKK Nv1;Nv3; Nv4 2470.51 Carboxypeptidase
FWGALIKGAAKLIPSVVGLFKK Nv1 2342.42 Carboxypeptidase
FWGALIKGAAKLIPSVVGLF Nv4 2086.23 Carboxypeptidase
FWGALIKGAAKLIPSVVGL Nv2;Nv4 1939.16 Carboxypeptidase
FWGALIKGAAKLIPSVVG Nv1; Nv3; Nv4 1826.08 Carboxypeptidase
FWGALIKGAAKLIPSVV Nv1 1769.06 Carboxypeptidase
 ALIKGAAKLIPSVVGLFKK Nv4 1952.25 Endopeptidase
 ALIKGAAKLIPSVVGLF Nv1 1696.06 Endopeptidase
 ALIKGAAKLIPSVVG Nv4 1548.99 Endopeptidase
 GAAKLIPSVVGLFKK Nv1 1526.95 Endopeptidase
 GAAKLIPSVVGLF Nv4 1270.76 Endopeptidase
 AAKLIPSVVGLF Nv1; 1213.74 Endopeptidase
 IPSVVGLFKK Nv4 1342.83 Endopeptidase
 PSVVGLFKKK Nv3; 1101.69 Endopeptidase
 IPSVVGLFK Nv4 958.58 Endopeptidase
 WGALIKGAAKLIPSVVGLFKKKQ Nv1; 2451.50 Aminopeptidase
 GALIKGAAKLIPSVVGLFKKKQ Nv4 2265.42 Aminopeptidase
 ALIKGAAKLIPSVVGLFKKKQ Nv1;Nv4 2208.40 Aminopeptidase
 IKGAAKLIPSVVGLFKKKQ Nv1; Nv4 2024.28 Aminopeptidase
 GAAKLIPSVVGLFKKKQ Nv1; Nv2;Nv4 1783.10 Aminopeptidase
 AAKLIPSVVGLFKKKQ Nv1;Nv2; Nv4 1726.08 Aminopeptidase
 PSVVGLFKKKQ Nv1; Nv2; Nv4 1229.74 Aminopeptidase
FWGALIKGAAKLIPSVVGMFKKKQ Nv1; Nv3; Nv4 2616.53 (Leu19Met)
FWGALIKGAAKLIPSVVGM Nv3 1957.12 (Leu19Met)/carboxypeptidase
 GALIKGAAKLIPSVVGMFKKKQ Nv3 2283.38 (Leu19Met)/aminopeptidase
 ALIKGAAKLIPSVVGMFKKKQ Nv3 2226.36 (Leu19Met)/aminopeptidase
 ALIKGAAKLIPSVVGM Nv3 1566.95 (Leu19Met)/endopeptidase
 GAAKLIPSVVGMFKKKQ Nv1;Nv3 1801.06 (Leu19Met)/endopeptidase
FW*GALIKGAAKLIPSVVGLFKKKQ Nv2; Nv4 2614.57 *Oxidation
FW*GALIKGAAKLIPSVVGL Nv2 1955.16 *Oxidation/carboxypeptidase
FW*GALIKGAAK Nv3 1176.66 *Oxidation/carboxypeptidase
  1. Nv1: winter; Nv2: summer; Nv3 ground-dwelling ants; Nv4: arboreal ants
  2. Bold letter indicates a mutation
  3. * Indicates an oxidation