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Fig. 5 | Journal of Venomous Animals and Toxins including Tropical Diseases

Fig. 5

From: Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells

Fig. 5

(a) ALT-C effects on MMP-9 expression in MDA-MB-231 cells, and (b) on MMP-2 mRNA levels in fibroblasts or (c) HMEC-1 cells. Levels of c-Myc mRNA after ALT-C treatment in (d) MDA-MB-231 cells, (e) human fibroblasts, and (f) HMEC-1 cells. The values represent relative transcript abundance and the p value was determined using ANOVA followed by Tukey’s test. Values were normalized to the level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA. The assay was performed in triplicate with two independent assays (n = 2). * p < 0.05, *** p < 0.001 compared to control (0 nM)

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