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Fig. 7 | Journal of Venomous Animals and Toxins including Tropical Diseases

Fig. 7

From: Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells

Fig. 7

Potential mechanism of ALT-C in the tumor microenvironment and cancer progression. (1) Transmigration of breast tumor cells (in blue) through endothelial cells is induced by low concentrations of ALT-C. (2) ALT-C binds to α2β1 integrin, triggering c-Myc upregulation via p-FAK and p-AKT activation resulting in downregulation of the proteins (3) MMP-9 and (4) MMP-2, thus decreasing tumor cell invasion into ECM. ALT-C also acts via α2β1 integrin on endothelial cells, decreasing MMP-2, which inhibits the formation of new blood vessels

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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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