Sodium channel
|
V1/2 activation (mV)
|
V1/2 inactivation (mV)
|
---|
Control
|
Venom
|
Control
|
Venom
|
---|
hNav 1.1
|
−22.4 ± 0.5
|
−26.5 ± 3.4
|
−52 ± 0.2
|
−53 ± 0.2
|
hNav 1.2
|
−25 ± 0.3
|
−43 ± 3
|
−61.6 ± 0.2
|
−66.9 ± 0.3
|
hNav 1.3
|
−20 ± 0.6
|
−19.9 ± 0.5
|
−53.9 ± 0.5
|
−52.6 ± 0.6
|
hNav 1.4
|
−4.2 ± 0.4
|
−4.4 ± 0.4
|
− 43.8 ± 0.3
|
−44.2 ± 1.4
|
hNav 1.5
|
−25.7 ± 0.3
|
−25 ± 0.3
|
−59.7 ± 0.3
|
60 ± 0.3
|
hNav 1.6
|
−22.8 ± 0.3
|
− 45.2 ± 1
|
−56.4 ± 0.3
|
−62.3 ± 0.2
|
hNav 1.7
|
−25.7 ± 0.3
|
−27 ± 0.4
|
−71.5 ± 0.4
|
70.6 ± 0.3
|
- V1/2 = middle activation or inactivation potential