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Table 1 Activity of PLA2 inhibitors against promastigote, amastigote and peritoneal macrophages from BALB/c mice

From: Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis

Compounds

EC50 (μΜ)a

CC50 (μM)

SIa

EC50 (μM)b

SIb

AA

450.1 ± 45.6

>  600

>  1.3

76.9 ± 5.7

>  7.8

BEL

15.1 ± 3.7

>  60

>  3.9

2.6 ± 0.8

>  23.1

MAFP

50.5 ± 7.8

>  300

>  5.9

17.6 ± 7.9

>  17.0

Miltefosine

12.6 ± 2.1

60.8 ± 3.1

4.8

21.6 ± 2.2

2.8

  1. The efficacies of compounds were analyzed through effective concentration 50 (EC50), and the selective indexes (SI) were estimated
  2. a promastigote; b amastigote