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Table 1 Activity of PLA2 inhibitors against promastigote, amastigote and peritoneal macrophages from BALB/c mice

From: Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis

Compounds EC50 (μΜ)a CC50 (μM) SIa EC50 (μM)b SIb
AA 450.1 ± 45.6 >  600 >  1.3 76.9 ± 5.7 >  7.8
BEL 15.1 ± 3.7 >  60 >  3.9 2.6 ± 0.8 >  23.1
MAFP 50.5 ± 7.8 >  300 >  5.9 17.6 ± 7.9 >  17.0
Miltefosine 12.6 ± 2.1 60.8 ± 3.1 4.8 21.6 ± 2.2 2.8
  1. The efficacies of compounds were analyzed through effective concentration 50 (EC50), and the selective indexes (SI) were estimated
  2. a promastigote; b amastigote