Fig. 5

Analysis of tissue lesion in thighs of uninfected mice. Evaluation of degree of tissue lesion (mean and SD) after administration of AWB and SAL at 48 h (a) (three administration under a five-day interval - Scheme 1) and at 2 h (b), 24 h (c), 48 h (d), 72 h (e) and 168 h (f) (unique administration - Scheme 2) post treatment. The tissue injury grade was assessed using the following classification: 0 = no change, 1 = mild localized inflammatory infiltrate, 2 = mild multifocal inflammatory infiltrate, 3 = moderate localized inflammatory infiltrate, 4 = moderate multifocal inflammatory infiltrate, 5 = severe diffuse inflammatory infiltrate. ANOVA (p ≤ 0.05) = *untreated/bled; # = individual analysis