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Table 1 The 4-Phenyl-1,3-thiazol-4-amines series

From: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents

Compound R CLogPa MRb Yield %
01 H 2.61 50.20 61
02 4-CH3 3.07 55.25 72
03 4-CH2CH3 3.47 59.85 59
04 3,4-Cl 3.64 59.81 53
05 4-CF3 3.49 56.18 18
06 4-C(CH3)3 4.23 68.87 27
07 4-OH 2.32 52.19 47
08 4-Cl 3.12 55.01 67
  1. (a) Calculated n-Octanol/Water Partition Coefficient; (b) Molar Refractivity