Table 1 The 4-Phenyl-1,3-thiazol-4-amines series
From: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Compound | R | CLogPa | MRb | Yield % |
|---|---|---|---|---|
01 | H | 2.61 | 50.20 | 61 |
02 | 4-CH3 | 3.07 | 55.25 | 72 |
03 | 4-CH2CH3 | 3.47 | 59.85 | 59 |
04 | 3,4-Cl | 3.64 | 59.81 | 53 |
05 | 4-CF3 | 3.49 | 56.18 | 18 |
06 | 4-C(CH3)3 | 4.23 | 68.87 | 27 |
07 | 4-OH | 2.32 | 52.19 | 47 |
08 | 4-Cl | 3.12 | 55.01 | 67 |