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Table 2 IC50 values against L. amazonensis promastigotes and the cytotoxicity assay results, expressed as CC50 values

From: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents

Compound IC50 (μM) pIC50 CC50 (μM) THP1 cellsa) SI CC50 (μM) L929 cellsb) SI CC50 (μM) VERO cellsc) SI
1 957.56 3.02 143.57 0.15 198.26 0.20 710.06 0.74
2 107.68 3.97 135.40 1.26 159.52 1.48 657.51 6.11
3 46.63 4.33 117.27 2.51 95.45 2.05 1217.5 26.11
4 53.12 4.27 84.65 1.59 121.12 2.28 255.03 4.80
5 53.37 4.27 92.21 1.73 106.08 2.00 511.76 9.59
6 20.78 4.68 45.73 2.20 27.07 1.30 118.17 5.69
7 inactive inactive inactive ND Inactive ND 651.29 ND
8 115.95 3.94 82.15 0.70 115.06 0.99 595.94 5.14
Amphotericin B 16.23 ND ND ND
Pentamidine 10.76 ND ND ND
  1.  (a) THP1 cells: human monocytic cell line derived from acute monocytic leukemia patients; (b) L929 cells: fibroblasts from subcutaneous connective tissue; c) Vero cells: kidney epithelial cells extracted from African green monkeys. IC50: Half-maximal inhibitory concentration on promastigotes; pIC50: Half-maximal inhibitory concentration in log units; CC50: Half cytotoxic concentration; SI: Selectivity Indexes, ND: Not determined. pIC50 calculates as pIC50 = −log10 (IC50)