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Table 1 Anti- Leishmania (L.) infantum (promastigote and amastigote forms) and mammalian cytotoxicity (NCTC cells) activities of compounds 1–6 isolated from Nectandra leucantha and eugenol/methyleugenol

From: Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity

Compounds EC50 (μM) 95% CI CC50 (μM) 95% CI SI Amastigote
Leishmania (L.) infantum NCTC
Amastigote Promastigote
1 NA NA >  200
2 57.9 (47.8–70.2) NA >  200 >  3.4
3 NA NA >  200
4 67.7 (54.5–84.2) 65.4 (59.7–72.3) >  200 >  2.9
5 NA NA 58.1
6 13.7 (11.7–16.0) 88.8 (76.2–103.7) >  200 >  14.6
eugenol NA NA >  200
methyleugenol NA NA >  200
miltefosine 16.9 (11.6–18.6) 16.4 (15.5–17.5) 122. 0 7.2
  1. EC50 50% effective concentration, CC50 50% cytotoxic concentration, SI selectivity index, NA Not Active 95%, CI 95% confidence interval