Table 1 Anti- Leishmania (L.) infantum (promastigote and amastigote forms) and mammalian cytotoxicity (NCTC cells) activities of compounds 1–6 isolated from Nectandra leucantha and eugenol/methyleugenol
Compounds | EC50 (μM) 95% CI | CC50 (μM) 95% CI | SI Amastigote | |
|---|---|---|---|---|
Leishmania (L.) infantum | NCTC | |||
Amastigote | Promastigote | |||
1 | NA | NA | > 200 | – |
2 | 57.9 (47.8–70.2) | NA | > 200 | > 3.4 |
3 | NA | NA | > 200 | – |
4 | 67.7 (54.5–84.2) | 65.4 (59.7–72.3) | > 200 | > 2.9 |
5 | NA | NA | 58.1 | – |
6 | 13.7 (11.7–16.0) | 88.8 (76.2–103.7) | > 200 | > 14.6 |
eugenol | NA | NA | > 200 | – |
methyleugenol | NA | NA | > 200 | – |
miltefosine | 16.9 (11.6–18.6) | 16.4 (15.5–17.5) | 122. 0 | 7.2 |