Fig. 3
From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
3D structure of TcIDH2 homology model. a Regions in blue represent Chain A and regions in yellow represent Chain B. The Ca2+ ions are indicated by green spheres. The two ligands presented in the stick model represent the co-factor NADP. b Interactions of sertraline with the allosteric binding site of TcIDH2 were predicted by docking. The residues of chain A are in blue and chain B is colored in yellow, indicating the interface that constitutes the allosteric binding site. In the center, sertraline carbon atoms are colored gray, nitrogen in blue, chlorine atoms are green and hydrogens are white. The hydrogen bond between sertraline and Gln276A is indicated by a green dashed line