Table 2 List of potential sertraline targets in T. cruzi
From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
SERT target | T. cruzi target | Biological process | E-value | Overlap | Active Site Conservation (%) |
|---|---|---|---|---|---|
Isocitrate dehydrogenase 1 | Isocitrate dehydrogenase 2 | isocitrate metabolism | 0 | 100% | High conservation (97%) |
Ubiquitin-conjugating enzyme E2 N | Ubiquitin-conjugating enzyme E2, purative | ubiquitin cycle | 1−68 | 96% | High conservation (76%) |
Cyclin-dependent kinase 1 | CDC2-related protein kinase 1, putative | protein phosphorylation | 2− 113 | 95% | High conservation (78%) |