Skip to main content

Table 2 List of potential sertraline targets in T. cruzi

From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

SERT target T. cruzi target Biological process E-value Overlap Active Site Conservation (%)
Isocitrate dehydrogenase 1 Isocitrate dehydrogenase 2 isocitrate metabolism 0 100% High conservation (97%)
Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2, purative ubiquitin cycle 1−68 96% High conservation (76%)
Cyclin-dependent kinase 1 CDC2-related protein kinase 1, putative protein phosphorylation 2− 113 95% High conservation (78%)