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Table 1 In vitro IC50 against promastigotes and amastigotes of Leishmania, CC50 against NCTC cells and SI

From: Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

Drugs

Promastigotes

IC50 (μM) (95%CI)

Amastigotes

IC50 (μM) (95%CI)

Cytotoxicity

CC50 (μM) (95%CI)

SI

Amiodarone

10.5

(9.5–11.7)

0.5

(0.1–2.0)

30.9

(12.5–76.1)

56.2

Miltefosine

16.8 (15.4–17.5)

17.8 (11.6–24.6)

122.0 (94.8–157.0)

6.8

  1. IC50 50% inhibitory concentration, CC50 50% cytotoxicity concentration, 95% C.I. 95% confidence interval, S.I selectivity index