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Table 1 In vitro IC50 against promastigotes and amastigotes of Leishmania, CC50 against NCTC cells and SI

From: Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

Drugs Promastigotes
IC50 (μM) (95%CI)
Amastigotes
IC50 (μM) (95%CI)
Cytotoxicity
CC50 (μM) (95%CI)
SI
Amiodarone 10.5
(9.5–11.7)
0.5
(0.1–2.0)
30.9
(12.5–76.1)
56.2
Miltefosine 16.8 (15.4–17.5) 17.8 (11.6–24.6) 122.0 (94.8–157.0) 6.8
  1. IC50 50% inhibitory concentration, CC50 50% cytotoxicity concentration, 95% C.I. 95% confidence interval, S.I selectivity index