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Table 4 The action spectrum of second-generation pterocarpanquinones on Leishmania and toxicity in macrophages

From: Second-generation pterocarpanquinones: synthesis and antileishmanial activity

Compounds Murine Macrophage L. amazonensis L. braziliensis L. infantum
Promastigote Amastigote SI d Promastigote Amastigote SI d Promastigote Amastigote SI d
CC50 (μM) IC50 (μM)   IC50 (μM)   IC50 (μM)  
LQB 187 (2a) 49.30 ± 1.10 1.05 ± 0.21 0.90 ± 0.10 54.7 23.10 ± 1.63 9.85 ± 1.37 5.0 1.20 ± 0.20 > 25 ND
LQB 182 (2b) 16.90 ± 1.20 1.08 ± 0.20 0.85 ± 0.02 19.8 10.98 ± 1.25 7.84 ± 2.46 2.15 1.00 ± 0.30 3.60 ± 0.90 4.69
LQB 236 (2c) 43.90 ± 0.60 1.15 ± 0.18 0.60 ± 0.13 73.16 17.85 ± 1.12 8.34 ± 1.47 5.26 1.80 ± 0.30 > 25 ND
LQB 168 (2d) 77.70 ± 1.10 1.37 ± 0.04 0.45 ± 0.06 172.6 28.21 ± 1.61 7.04 ± 2.29 11.03 2.00 ± 0.40 > 50 ND
LQB 474 (2e) 14.92 ± 1.43 0.50 ± 0.07 2.60 ± 0.8 5.74 12.34 ± 0.45 8.53 ± 1.12 1.74 2.20 ± 0.30 > 10 ND
LQB 475 (2f) 49.90 ± .1.00 0.40 ± 0.06 2.10 ± 0.4 23.76 10.50 ± 1.01 9.02 ± 1.64 5.53 1.40 ± 0.70 > 40 ND
LQB-118 (1) 18.46 a 1.73 a 1.45 a 12.73 3.40 b 7.50 b 2.46 4.08 c 3.25 c 5.68
Pentamidine 8.50 ± 1.25 4.80 ± 0.09 1.90 ± 0.10 4.47 13.0 ± 0.04 7.70 ± 2.40 1.1 5.70 ± 0.12 0.40 ± 0.20 21.25
  1. ND Not Determined
  2. a reference [14]
  3. b reference [13] e
  4. c reference [12]
  5. d Selective Index (SI) = CC50 in Macrophages/IC50 in intracellular amastigotes