Table 4 The action spectrum of second-generation pterocarpanquinones on Leishmania and toxicity in macrophages
From: Second-generation pterocarpanquinones: synthesis and antileishmanial activity
Compounds | Murine Macrophage | L. amazonensis | L. braziliensis | L. infantum | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Promastigote | Amastigote | SI d | Promastigote | Amastigote | SI d | Promastigote | Amastigote | SI d | ||
CC50 (μM) | IC50 (μM) | IC50 (μM) | IC50 (μM) | |||||||
LQB 187 (2a) | 49.30 ± 1.10 | 1.05 ± 0.21 | 0.90 ± 0.10 | 54.7 | 23.10 ± 1.63 | 9.85 ± 1.37 | 5.0 | 1.20 ± 0.20 | > 25 | ND |
LQB 182 (2b) | 16.90 ± 1.20 | 1.08 ± 0.20 | 0.85 ± 0.02 | 19.8 | 10.98 ± 1.25 | 7.84 ± 2.46 | 2.15 | 1.00 ± 0.30 | 3.60 ± 0.90 | 4.69 |
LQB 236 (2c) | 43.90 ± 0.60 | 1.15 ± 0.18 | 0.60 ± 0.13 | 73.16 | 17.85 ± 1.12 | 8.34 ± 1.47 | 5.26 | 1.80 ± 0.30 | > 25 | ND |
LQB 168 (2d) | 77.70 ± 1.10 | 1.37 ± 0.04 | 0.45 ± 0.06 | 172.6 | 28.21 ± 1.61 | 7.04 ± 2.29 | 11.03 | 2.00 ± 0.40 | > 50 | ND |
LQB 474 (2e) | 14.92 ± 1.43 | 0.50 ± 0.07 | 2.60 ± 0.8 | 5.74 | 12.34 ± 0.45 | 8.53 ± 1.12 | 1.74 | 2.20 ± 0.30 | > 10 | ND |
LQB 475 (2f) | 49.90 ± .1.00 | 0.40 ± 0.06 | 2.10 ± 0.4 | 23.76 | 10.50 ± 1.01 | 9.02 ± 1.64 | 5.53 | 1.40 ± 0.70 | > 40 | ND |
LQB-118 (1) | 18.46 a | 1.73 a | 1.45 a | 12.73 | 3.40 b | 7.50 b | 2.46 | 4.08 c | 3.25 c | 5.68 |
Pentamidine | 8.50 ± 1.25 | 4.80 ± 0.09 | 1.90 ± 0.10 | 4.47 | 13.0 ± 0.04 | 7.70 ± 2.40 | 1.1 | 5.70 ± 0.12 | 0.40 ± 0.20 | 21.25 |