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Table 5 Analysis of Δѱm. index of variation (IV) of L. infantum promastigotes treated with LQBs

From: Second-generation pterocarpanquinones: synthesis and antileishmanial activity

Compounds

μM

Index of variation a

Control

0

0

LQB 187 (2A)

1.25

−0.103 ± 0.16

2.5

−0.368 ± 0.03

LQB 182 (2B)

1.25

−0.397 ± 0.07

2.5

−0.402 ± 0.04

LQB 236 (2C)

1.25

−0.360 ± 0.16

2.5

−0.258 ± 0.17

LQB 168 (2D)

1.25

−0.369 ± 0.08

2.5

−0.194 ± 0.18

LQB 474 (2E)

1.25

−0.582 ± 0.1

2.5

−0.701 ± 0.01

LQB 475 (2F)

1.25

−0.668 ± 0.01

2.5

−0.707 ± 0.01

FCCP

20

−0.727 ± 0.01

  1. Values refer to the mean and standard deviation of three experiments
  2. MT median fluorescence of treated parasites, MC median fluorescence of control parasites
  3. a The changes in the fluorescence intensity of rhodamine 123 were quantified from the index of variation obtained by the equation (MT – MC) / MC
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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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