Fig. 3
From: Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
Crotoxin’s immunosuppressive modulation. Blood circulation, lymph node homing of lymphocytes and cellular events associated with the immunosuppressive effects of Crotoxin and its subunits. The figure illustrates the capacity of Crotoxin to modulate migration (adherence and chemotaxis), function (proliferation), expression of adhesion molecules (L-selectin and LFA-1), and inflammatory mediators (IL-2, IL-4, IL-10 and INF-γ) of circulating and lymph node lymphocytes, as well as imunoglobulins production (IgG1 and IgG2a). Green arrows indicate cells/events that are stimulated by Crotoxin, while red arrows indicate reduction or inhibition. The illustration was created using Mind the Graph platform (www.mindthegraph.com)