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  1. Review

    The modular nature of bradykinin-potentiating peptides isolated from snake venoms

    Bradykinin-potentiating peptides (BPPs) are molecules discovered by Sergio Ferreira – who found them in the venom of Bothrops jararaca in the 1960s – that literally potentiate the action of bradykinin in vivo by,...

    Juliana Mozer Sciani and Daniel Carvalho Pimenta

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:45

    Published on: 26 October 2017

  2. Review

    It is time for top-down venomics

    The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoform...

    Rafael D. Melani, Fabio C. S. Nogueira and Gilberto B. Domont

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:44

    Published on: 18 October 2017

  3. Research

    Preliminary molecular characterization of a proinflammatory and nociceptive molecule from the Echinometra lucunter spines extracts

    Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, a...

    Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira and Daniel Carvalho Pimenta

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:43

    Published on: 3 October 2017

  4. Research

    In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease

    The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning...

    Maleeha Waqar and Sidra Batool

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:42

    Published on: 20 September 2017

  5. Review

    Zika virus congenital syndrome: experimental models and clinical aspects

    Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, ...

    Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui and Jean Pierre Schatzmann Peron

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:41

    Published on: 15 September 2017

  6. Research

    Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans

    Among the hymenopteran insect venoms, those from social wasps and bees – such as honeybee, hornets and paper wasps – have been well documented. Their venoms are composed of a number of peptides and proteins an...

    Kohei Kazuma, Kenji Ando, Ken-ichi Nihei, Xiaoyu Wang, Marisa Rangel, Marcia Regina Franzolin, Kanami Mori-Yasumoto, Setsuko Sekita, Makoto Kadowaki, Motoyoshi Satake and Katsuhiro Konno

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:40

    Published on: 29 August 2017

  7. Research

    Predictive determinants of scorpion stings in a tropical zone of south Iran: use of mixed seasonal autoregressive moving average model

    More than 1.2 million scorpion stings occur annually worldwide, particularly in tropical regions. In the absence of proper medical care, mortality due to venomous scorpion stings is an important public health ...

    Vahid Ebrahimi, Esmael Hamdami, Mohammad Djaefar Moemenbellah-Fard and Shahrokh Ezzatzadegan Jahromi

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:39

    Published on: 23 August 2017

  8. Letter to the Editor

    Snakebite envenomation turns again into a neglected tropical disease!

    On June 9th, 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches...

    Jean-Philippe Chippaux

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:38

    Published on: 8 August 2017

  9. Research

    Preparation of monoclonal antibodies against gamma-type phospholipase A2 inhibitors and immunodetection of these proteins in snake blood

    The gamma-type phospholipase A2 inhibitor (PLIγ) is a natural protein commonly found in snake serum, which can neutralize pathophysiological effects of snake venom phospholipases A2. Therefore, this protein is a ...

    Jingjing Li, Ying Xiong, Shimin Sun, Lehan Yu and Chunhong Huang

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:37

    Published on: 3 August 2017

  10. Research

    BaltDC: purification, characterization and infrared spectroscopy of an antiplatelet DC protein isolated from Bothrops alternatus snake venom

    Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disord...

    Mariana Santos Matias, Bruna Barbosa de Sousa, Déborah Fernanda da Cunha Pereira, Edigar Henrique Vaz Dias, Carla Cristine Neves Mamede, Mayara Ribeiro de Queiroz, Anielle Christine Almeida Silva, Noelio Oliveira Dantas, Andreimar Martins Soares, Júnia de Oliveira Costa and Fábio de Oliveira

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:36

    Published on: 28 July 2017

  11. Research

    In vitro characterization of jellyfish venom fibrin(ogen)olytic enzymes from Nemopilema nomurai

    Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, bi...

    Seong Kyeong Bae, Hyunkyoung Lee, Yunwi Heo, Min Jung Pyo, Indu Choudhary, Chang Hoon Han, Won Duk Yoon, Changkeun Kang and Euikyung Kim

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:35

    Published on: 19 July 2017

  12. Research

    Mathematical modelling of vector-borne diseases and insecticide resistance evolution

    Vector-borne diseases are important public health issues and, consequently, in silico models that simulate them can be useful. The susceptible-infected-recovered (SIR) model simulates the population dynamics o...

    Maria Laura Gabriel Kuniyoshi and Fernando Luiz Pio dos Santos

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:34

    Published on: 6 July 2017

  13. Research

    Isolation and biochemical characterization of bradykinin-potentiating peptides from Bitis gabonica rhinoceros

    Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (B...

    Tamara M. Fucase, Juliana M. Sciani, Ingrid Cavalcante, Vincent L. Viala, Bruno B. Chagas, Daniel C. Pimenta and Patrick J. Spencer

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:33

    Published on: 26 June 2017

  14. Review

    Jaburetox: update on a urease-derived peptide

    Urease from Canavalia ensiformis seeds was the first enzyme ever to be crystallized, in 1926. These proteins, found in plants, bacteria and fungi, present different biological properties including catalytic hydro...

    Arlete Beatriz Becker-Ritt, Camila Saretta Portugal and Célia Regina Carlini

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:32

    Published on: 15 June 2017

  15. Review

    Perinatal effects of scorpion venoms: maternal and offspring development

    Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possib...

    Ana Leticia Coronado Dorce, Adriana do Nascimento Martins, Valquiria Abrão Coronado Dorce and Ana Leonor Abrahão Nencioni

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:31

    Published on: 14 June 2017

  16. Research

    Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

    Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern am...

    Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta and Andre Gustavo Tempone

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:30

    Published on: 30 May 2017

  17. Research

    Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata

    Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfull...

    Hiroko Kawakami, Shin G. Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki and Tetsuro Shinada

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:29

    Published on: 23 May 2017

  18. Short report

    Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

    Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable i...

    Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali and Carlos Correa-Netto

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:28

    Published on: 12 May 2017

  19. Review

    Protein-species quantitative venomics: looking through a crystal ball

    In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level...

    Juan J. Calvete, Daniel Petras, Francisco Calderón-Celis, Bruno Lomonte, Jorge Ruiz Encinar and Alfredo Sanz-Medel

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:27

    Published on: 28 April 2017

  20. Review

    Strategies in ‘snake venomics’ aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

    This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achie...

    Bruno Lomonte and Juan J. Calvete

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:26

    Published on: 28 April 2017

  21. Case report

    Neurological complications and death in children with dengue virus infection: report of two cases

    Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurologica...

    Neydi Osnaya-Romero, Maria-Gabriela Perez-Guille, Sandra Andrade-García, Erika Gonzalez-Vargas, Rebeca Borgaro-Payro, Sandra Villagomez-Martinez, José de Jesús Ortega-Maldonado and Jose Luis Arredondo-García

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:25

    Published on: 27 April 2017

  22. Research Article

    Rattlesnake Crotalus molossus nigrescens venom induces oxidative stress on human erythrocytes

    Globally, snake envenomation is a well-known cause of death and morbidity. In many cases of snakebite, myonecrosis, dermonecrosis, hemorrhage and neurotoxicity are present. Some of these symptoms may be provok...

    David Meléndez-Martínez, Juan Manuel Muñoz, Guillermo Barraza-Garza, Martha Sandra Cruz-Peréz, Ana Gatica-Colima, Emilio Alvarez-Parrilla and Luis Fernando Plenge-Tellechea

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:24

    Published on: 21 April 2017

  23. Short report

    Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori

    Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between th...

    Marina Saes, Roger Willian de Labio, Lucas Trevizani Rasmussen and Spencer Luiz Marques Payão

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:23

    Published on: 8 April 2017

  24. Review

    Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

    Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin seal...

    Rui Seabra Ferreira Jr, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari dos Santos and Benedito Barraviera

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:21

    Published on: 4 April 2017

  25. Research

    Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom

    The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snak...

    Jinhua Liu, Qiyi He, Wenwen Wang, Bin Zhou, Bo Li, Yingfeng Zhang, Cong Luo, Diancheng Chen, Jia Tang and Xiaodong Yu

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:22

    Published on: 4 April 2017

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