Figure 4

Maintenance of the blood-testis barrier (BTB) in male adult mice treated with vehicle, captopril or BPP-10c. Photomicrographs of 0.5-μm thick – plastic-embedded transverse sections of (A) vehicle, (B) captopril, (C) BPP-10c and (D) LPS – of seminiferous tubules following fixation with hyperosmotic fixative and staining with hematoxylin and eosin. The adluminal meiotic cells are protected from fixative-induced condensation, maintaining normal morphology and cellular contacts in A, B and C (arrow). The BTB is not maintained in the seminiferous tubules of mice treated with LPS (D, see arrow).