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  1. Content type: Research

    Loxoscelism is a severe human envenomation caused by Loxosceles spider venom. To the best of our knowledge, no study has evaluated the presence of antibodies against Loxosceles venom in loxoscelism patients witho...

    Authors: Tomás Arán-Sekul, José M. Rojas, Mario Subiabre, Victoria Cruz, William Cortés, Luis Osorio, Jorge González, Jorge E. Araya and Alejandro Catalán

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:18

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  2. Content type: Research

    Centruroides hirsutipalpus, of the family Buthidae, is a scorpion endemic to the Western Pacific region of Mexico. Although medically important, its venom has not yet been studied. Therefore, this communication a...

    Authors: Laura L. Valdez-Velázquez, Timoteo Olamendi-Portugal, Rita Restano-Cassulini, Fernando Z. Zamudio and Lourival D. Possani

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:17

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  3. Content type: Research

    Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies. The effectiveness of serum...

    Authors: Carla Cristina Squaiella-Baptistão, Fábio Carlos Magnoli, José Roberto Marcelino, Osvaldo Augusto Sant’Anna and Denise V. Tambourgi

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:16

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  4. Content type: Review

    In general, clinical research network capacity building refers to programs aimed at enhancing networks of researchers to conduct clinical research. Although in the literature there is a large body of research ...

    Authors: Guowei Li, Qianyu Wu, Yanling Jin, Thuva Vanniyasingam and Lehana Thabane

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:15

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  5. Content type: Research

    The whole blood clotting test (WBCT) is a simple test of coagulation that is often used in the assessment, diagnosis, and therapeutic monitoring of snakebite patients in sub-Saharan Africa. WBCT requires only ...

    Authors: Jordan Max Benjamin, Jean-Philippe Chippaux, Bio Tamou Sambo and Achille Massougbodji

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:14

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  6. Content type: Research

    Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion rece...

    Authors: Milene Nóbrega de Oliveira Moritz, Lívia Mara Santos Eustáquio, Kelli Cristina Micocci, Ana Carolina Caetano Nunes, Patty Karina dos Santos, Tamires de Castro Vieira and Heloísa Sobreiro Selistre-de-Araujo

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:13

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  7. Content type: Research

    Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or j...

    Authors: Fernando Lazcano-Pérez, Ariana Zavala-Moreno, Yadira Rufino-González, Martha Ponce-Macotela, Alejandro García-Arredondo, Miguel Cuevas-Cruz, Saúl Gómez-Manzo, Jaime Marcial-Quino, Barbarín Arreguín-Lozano and Roberto Arreguín-Espinosa

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:12

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  8. Content type: Research

    Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve gra...

    Authors: Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira Jr, Benedito Barraviera and Alexandre Leite Rodrigues Oliveira

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:11

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  9. Content type: Case report

    Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus, which together represent almost 80% of a...

    Authors: Marcelo Abrahão Strauch, Guilherme Jones Souza, Jordana Nahar Pereira, Tyelli dos Santos Ramos, Marcelo Oliveira Cesar, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto and Paulo A. Melo

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:10

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  10. Content type: Research

    Envenoming by kraits (genus Bungarus) is a medically significant issue in South Asia and Southeast Asia. Malayan krait (Bungarus candidus) venom is known to contain highly potent neurotoxins. In recent years, the...

    Authors: Mongkon Charoenpitakchai, Kulachet Wiwatwarayos, Nattapon Jaisupa, Muhamad Rusdi Ahmad Rusmili, Supachoke Mangmool, Wayne C. Hodgson, Chetana Ruangpratheep, Lawan Chanhome and Janeyuth Chaisakul

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:9

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  11. Content type: Review

    Scorpions are distributed throughout Iran and the genus Hemiscorpius is particularly important in this region. Hemiscorpius lepturus is the most significant species within the genus in the country. Since scorpion...

    Authors: Rouhullah Dehghani, Fatemeh Kamiabi and Malihe Mohammadi

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:8

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  12. Content type: Research

    Advancements in proteomics, including the technological improvement in instrumentation, have turned mass spectrometry into an indispensable tool in the study of venoms and toxins. In addition, the advance of n...

    Authors: Camila Takeno Cologna, Renata Santos Rodrigues, Jean Santos, Edwin de Pauw, Eliane Candiani Arantes and Loïc Quinton

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:6

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  13. Content type: Research

    Wasp venoms constitute a molecular reservoir of new pharmacological substances such as peptides and proteins, biological property holders, many of which are yet to be identified. Exploring these sources may le...

    Authors: Rafaela Diniz-Sousa, Anderson M. Kayano, Cleópatra A. Caldeira, Rodrigo Simões-Silva, Marta C. Monteiro, Leandro S. Moreira-Dill, Fernando P. Grabner, Leonardo A. Calderon, Juliana P. Zuliani, Rodrigo G. Stábeli and Andreimar M. Soares

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:5

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  14. Content type: Editorial

    This editorial provides a brief overview of the importance of pilot or feasibility trials or studies, the challenges with current practices in their conduct and reporting, an introduction to the Consolidated S...

    Authors: Luciana P. F. Abbade, Joelcio F. Abbade and Lehana Thabane

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:4

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  15. Content type: Research

    Sperm contains a wealth of cell surface receptors and ion channels that are required for most of its basic functions such as motility and acrosome reaction. Conversely, animal venoms are enriched in bioactive ...

    Authors: Tarek Mohamed Abd El-Aziz, Sawsan Al Khoury, Lucie Jaquillard, Mathilde Triquigneaux, Guillaume Martinez, Sandrine Bourgoin-Voillard, Michel Sève, Christophe Arnoult, Rémy Beroud and Michel De Waard

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:2

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  16. Content type: Review

    In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other...

    Authors: Ana Leonor Abrahão Nencioni, Emidio Beraldo Neto, Lucas Alves de Freitas and Valquiria Abrão Coronado Dorce

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2018 24:3

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  17. Content type: Research

    The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental ...

    Authors: Mariana Gatto, Larissa Ragozo Cardoso Oliveira, Fernanda De Nuzzi Dias, João Pessoa Araújo Júnior, Carlos Roberto Gonçalves Lima, Eliana Peresi Lordelo, Rodrigo Mattos dos Santos and Cilmery Suemi Kurokawa

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:47

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  18. Content type: Research

    Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin....

    Authors: Laudicéia Alves de Oliveira, Rui Seabra Ferreira Jr, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos and Daniel Carvalho Pimenta

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:46

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  19. Content type: Review

    Bradykinin-potentiating peptides (BPPs) are molecules discovered by Sergio Ferreira – who found them in the venom of Bothrops jararaca in the 1960s – that literally potentiate the action of bradykinin in vivo by,...

    Authors: Juliana Mozer Sciani and Daniel Carvalho Pimenta

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:45

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  20. Content type: Review

    The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoform...

    Authors: Rafael D. Melani, Fabio C. S. Nogueira and Gilberto B. Domont

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:44

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  21. Content type: Research

    Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, a...

    Authors: Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira and Daniel Carvalho Pimenta

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:43

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  22. Content type: Research

    The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning...

    Authors: Maleeha Waqar and Sidra Batool

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:42

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  23. Content type: Review

    Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, ...

    Authors: Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui and Jean Pierre Schatzmann Peron

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:41

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  24. Content type: Research

    Among the hymenopteran insect venoms, those from social wasps and bees – such as honeybee, hornets and paper wasps – have been well documented. Their venoms are composed of a number of peptides and proteins an...

    Authors: Kohei Kazuma, Kenji Ando, Ken-ichi Nihei, Xiaoyu Wang, Marisa Rangel, Marcia Regina Franzolin, Kanami Mori-Yasumoto, Setsuko Sekita, Makoto Kadowaki, Motoyoshi Satake and Katsuhiro Konno

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:40

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  25. Content type: Research

    More than 1.2 million scorpion stings occur annually worldwide, particularly in tropical regions. In the absence of proper medical care, mortality due to venomous scorpion stings is an important public health ...

    Authors: Vahid Ebrahimi, Esmael Hamdami, Mohammad Djaefar Moemenbellah-Fard and Shahrokh Ezzatzadegan Jahromi

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:39

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  26. Content type: Letter to the Editor

    On June 9th, 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches...

    Authors: Jean-Philippe Chippaux

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:38

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  27. Content type: Research

    The gamma-type phospholipase A2 inhibitor (PLIγ) is a natural protein commonly found in snake serum, which can neutralize pathophysiological effects of snake venom phospholipases A2. Therefore, this protein is a ...

    Authors: Jingjing Li, Ying Xiong, Shimin Sun, Lehan Yu and Chunhong Huang

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:37

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  28. Content type: Research

    Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disord...

    Authors: Mariana Santos Matias, Bruna Barbosa de Sousa, Déborah Fernanda da Cunha Pereira, Edigar Henrique Vaz Dias, Carla Cristine Neves Mamede, Mayara Ribeiro de Queiroz, Anielle Christine Almeida Silva, Noelio Oliveira Dantas, Andreimar Martins Soares, Júnia de Oliveira Costa and Fábio de Oliveira

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:36

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  29. Content type: Research

    Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, bi...

    Authors: Seong Kyeong Bae, Hyunkyoung Lee, Yunwi Heo, Min Jung Pyo, Indu Choudhary, Chang Hoon Han, Won Duk Yoon, Changkeun Kang and Euikyung Kim

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:35

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  30. Content type: Research

    Vector-borne diseases are important public health issues and, consequently, in silico models that simulate them can be useful. The susceptible-infected-recovered (SIR) model simulates the population dynamics o...

    Authors: Maria Laura Gabriel Kuniyoshi and Fernando Luiz Pio dos Santos

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:34

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  31. Content type: Research

    Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (B...

    Authors: Tamara M. Fucase, Juliana M. Sciani, Ingrid Cavalcante, Vincent L. Viala, Bruno B. Chagas, Daniel C. Pimenta and Patrick J. Spencer

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:33

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  32. Content type: Review

    Urease from Canavalia ensiformis seeds was the first enzyme ever to be crystallized, in 1926. These proteins, found in plants, bacteria and fungi, present different biological properties including catalytic hydro...

    Authors: Arlete Beatriz Becker-Ritt, Camila Saretta Portugal and Célia Regina Carlini

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:32

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  33. Content type: Review

    Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possib...

    Authors: Ana Leticia Coronado Dorce, Adriana do Nascimento Martins, Valquiria Abrão Coronado Dorce and Ana Leonor Abrahão Nencioni

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:31

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  34. Content type: Research

    Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern am...

    Authors: Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta and Andre Gustavo Tempone

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:30

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  35. Content type: Research

    Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfull...

    Authors: Hiroko Kawakami, Shin G. Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki and Tetsuro Shinada

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:29

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  36. Content type: Short report

    Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable i...

    Authors: Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali and Carlos Correa-Netto

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:28

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  37. Content type: Review

    In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level...

    Authors: Juan J. Calvete, Daniel Petras, Francisco Calderón-Celis, Bruno Lomonte, Jorge Ruiz Encinar and Alfredo Sanz-Medel

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:27

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  38. Content type: Review

    This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achie...

    Authors: Bruno Lomonte and Juan J. Calvete

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:26

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  39. Content type: Case report

    Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurologica...

    Authors: Neydi Osnaya-Romero, Maria-Gabriela Perez-Guille, Sandra Andrade-García, Erika Gonzalez-Vargas, Rebeca Borgaro-Payro, Sandra Villagomez-Martinez, José de Jesús Ortega-Maldonado and Jose Luis Arredondo-García

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:25

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  40. Content type: Research Article

    Globally, snake envenomation is a well-known cause of death and morbidity. In many cases of snakebite, myonecrosis, dermonecrosis, hemorrhage and neurotoxicity are present. Some of these symptoms may be provok...

    Authors: David Meléndez-Martínez, Juan Manuel Muñoz, Guillermo Barraza-Garza, Martha Sandra Cruz-Peréz, Ana Gatica-Colima, Emilio Alvarez-Parrilla and Luis Fernando Plenge-Tellechea

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:24

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  41. Content type: Short report

    Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between th...

    Authors: Marina Saes, Roger Willian de Labio, Lucas Trevizani Rasmussen and Spencer Luiz Marques Payão

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:23

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  42. Content type: Review

    Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin seal...

    Authors: Rui Seabra Ferreira Jr, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari dos Santos and Benedito Barraviera

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:21

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  43. Content type: Research

    The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snak...

    Authors: Jinhua Liu, Qiyi He, Wenwen Wang, Bin Zhou, Bo Li, Yingfeng Zhang, Cong Luo, Diancheng Chen, Jia Tang and Xiaodong Yu

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:22

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  44. Content type: Research

    Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated patholo...

    Authors: Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury and Gisele Picolo

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:18

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  45. Content type: Review

    It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomou...

    Authors: Norival A. Santos-Filho and Claudia T. Santos

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:19

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  46. Content type: Research

    Agaricus brasiliensis is a medicinal mushroom with immunomodulatory and antitumor activities attributed to the β-glucans presented in the polysaccharide fraction of its fruiting body. ...

    Authors: Priscila Raquel Martins, Ângela Maria Victoriano de Campos Soares, Andrea Vanessa da Silva Pinto Domeneghini, Márjorie Assis Golim and Ramon Kaneno

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:17

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  47. Content type: Case report

    Deinagkistrodon acutus envenomation is associated with severe hematological and wound complications but is rarely described.

    Authors: Chin-Lung Cheng, Yan-Chiao Mao, Po-Yu Liu, Liao-Chun Chiang, Shu-Chen Liao and Chen-Chang Yang

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:20

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  48. Content type: Case report

    Cardiotoxicity is a documented complication of Crotalinae envenomation. Reported cardiac complications following snake envenomation have included acute myocardial infarction, electrocardiogram abnormalities an...

    Authors: Dan Quan and Kenneth Zurcher

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:16

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