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  1. Letter to the Editor

    Snakebite envenomation turns again into a neglected tropical disease!

    On June 9th, 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches...

    Jean-Philippe Chippaux

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:38

    Published on: 8 August 2017

  2. Research

    Preparation of monoclonal antibodies against gamma-type phospholipase A2 inhibitors and immunodetection of these proteins in snake blood

    The gamma-type phospholipase A2 inhibitor (PLIγ) is a natural protein commonly found in snake serum, which can neutralize pathophysiological effects of snake venom phospholipases A2. Therefore, this protein is a ...

    Jingjing Li, Ying Xiong, Shimin Sun, Lehan Yu and Chunhong Huang

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:37

    Published on: 3 August 2017

  3. Research

    BaltDC: purification, characterization and infrared spectroscopy of an antiplatelet DC protein isolated from Bothrops alternatus snake venom

    Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disord...

    Mariana Santos Matias, Bruna Barbosa de Sousa, Déborah Fernanda da Cunha Pereira, Edigar Henrique Vaz Dias, Carla Cristine Neves Mamede, Mayara Ribeiro de Queiroz, Anielle Christine Almeida Silva, Noelio Oliveira Dantas, Andreimar Martins Soares, Júnia de Oliveira Costa and Fábio de Oliveira

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:36

    Published on: 28 July 2017

  4. Research

    In vitro characterization of jellyfish venom fibrin(ogen)olytic enzymes from Nemopilema nomurai

    Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, bi...

    Seong Kyeong Bae, Hyunkyoung Lee, Yunwi Heo, Min Jung Pyo, Indu Choudhary, Chang Hoon Han, Won Duk Yoon, Changkeun Kang and Euikyung Kim

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:35

    Published on: 19 July 2017

  5. Research

    Mathematical modelling of vector-borne diseases and insecticide resistance evolution

    Vector-borne diseases are important public health issues and, consequently, in silico models that simulate them can be useful. The susceptible-infected-recovered (SIR) model simulates the population dynamics o...

    Maria Laura Gabriel Kuniyoshi and Fernando Luiz Pio dos Santos

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:34

    Published on: 6 July 2017

  6. Research

    Isolation and biochemical characterization of bradykinin-potentiating peptides from Bitis gabonica rhinoceros

    Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (B...

    Tamara M. Fucase, Juliana M. Sciani, Ingrid Cavalcante, Vincent L. Viala, Bruno B. Chagas, Daniel C. Pimenta and Patrick J. Spencer

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:33

    Published on: 26 June 2017

  7. Review

    Jaburetox: update on a urease-derived peptide

    Urease from Canavalia ensiformis seeds was the first enzyme ever to be crystallized, in 1926. These proteins, found in plants, bacteria and fungi, present different biological properties including catalytic hydro...

    Arlete Beatriz Becker-Ritt, Camila Saretta Portugal and Célia Regina Carlini

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:32

    Published on: 15 June 2017

  8. Review

    Perinatal effects of scorpion venoms: maternal and offspring development

    Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possib...

    Ana Leticia Coronado Dorce, Adriana do Nascimento Martins, Valquiria Abrão Coronado Dorce and Ana Leonor Abrahão Nencioni

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:31

    Published on: 14 June 2017

  9. Research

    Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

    Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern am...

    Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta and Andre Gustavo Tempone

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:30

    Published on: 30 May 2017

  10. Research

    Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata

    Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfull...

    Hiroko Kawakami, Shin G. Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki and Tetsuro Shinada

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:29

    Published on: 23 May 2017

  11. Short report

    Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

    Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable i...

    Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali and Carlos Correa-Netto

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:28

    Published on: 12 May 2017

  12. Review

    Protein-species quantitative venomics: looking through a crystal ball

    In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level...

    Juan J. Calvete, Daniel Petras, Francisco Calderón-Celis, Bruno Lomonte, Jorge Ruiz Encinar and Alfredo Sanz-Medel

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:27

    Published on: 28 April 2017

  13. Review

    Strategies in ‘snake venomics’ aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

    This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achie...

    Bruno Lomonte and Juan J. Calvete

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:26

    Published on: 28 April 2017

  14. Case report

    Neurological complications and death in children with dengue virus infection: report of two cases

    Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurologica...

    Neydi Osnaya-Romero, Maria-Gabriela Perez-Guille, Sandra Andrade-García, Erika Gonzalez-Vargas, Rebeca Borgaro-Payro, Sandra Villagomez-Martinez, José de Jesús Ortega-Maldonado and Jose Luis Arredondo-García

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:25

    Published on: 27 April 2017

  15. Research Article

    Rattlesnake Crotalus molossus nigrescens venom induces oxidative stress on human erythrocytes

    Globally, snake envenomation is a well-known cause of death and morbidity. In many cases of snakebite, myonecrosis, dermonecrosis, hemorrhage and neurotoxicity are present. Some of these symptoms may be provok...

    David Meléndez-Martínez, Juan Manuel Muñoz, Guillermo Barraza-Garza, Martha Sandra Cruz-Peréz, Ana Gatica-Colima, Emilio Alvarez-Parrilla and Luis Fernando Plenge-Tellechea

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:24

    Published on: 21 April 2017

  16. Short report

    Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori

    Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between th...

    Marina Saes, Roger Willian de Labio, Lucas Trevizani Rasmussen and Spencer Luiz Marques Payão

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:23

    Published on: 8 April 2017

  17. Review

    Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview

    Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin seal...

    Rui Seabra Ferreira Jr, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari dos Santos and Benedito Barraviera

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:21

    Published on: 4 April 2017

  18. Research

    Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom

    The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snak...

    Jinhua Liu, Qiyi He, Wenwen Wang, Bin Zhou, Bo Li, Yingfeng Zhang, Cong Luo, Diancheng Chen, Jia Tang and Xiaodong Yu

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:22

    Published on: 4 April 2017

  19. Research

    Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

    Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated patholo...

    Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury and Gisele Picolo

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:18

    Published on: 23 March 2017

  20. Review

    Alpha-type phospholipase A2 inhibitors from snake blood

    It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomou...

    Norival A. Santos-Filho and Claudia T. Santos

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:19

    Published on: 23 March 2017

  21. Research

    Agaricus brasiliensis polysaccharides stimulate human monocytes to capture Candida albicans, express toll-like receptors 2 and 4, and produce pro-inflammatory cytokines

    Agaricus brasiliensis is a medicinal mushroom with immunomodulatory and antitumor activities attributed to the β-glucans presented in the polysaccharide fraction of its fruiting body. ...

    Priscila Raquel Martins, Ângela Maria Victoriano de Campos Soares, Andrea Vanessa da Silva Pinto Domeneghini, Márjorie Assis Golim and Ramon Kaneno

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:17

    Published on: 23 March 2017

  22. Case report

    Deinagkistrodon acutus envenomation: a report of three cases

    Deinagkistrodon acutus envenomation is associated with severe hematological and wound complications but is rarely described.

    Chin-Lung Cheng, Yan-Chiao Mao, Po-Yu Liu, Liao-Chun Chiang, Shu-Chen Liao and Chen-Chang Yang

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:20

    Published on: 23 March 2017

  23. Case report

    Reversible atrial fibrillation following Crotalinae envenomation

    Cardiotoxicity is a documented complication of Crotalinae envenomation. Reported cardiac complications following snake envenomation have included acute myocardial infarction, electrocardiogram abnormalities an...

    Dan Quan and Kenneth Zurcher

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:16

    Published on: 21 March 2017

  24. Research

    A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom

    Envenomation caused by multiple stings from Africanized honeybees Apis mellifera constitutes a public health problem in the Americas. In 2015, the Brazilian Ministry of Health reported 13,597 accidents (incidence...

    Alexandre Naime Barbosa, Leslie Boyer, Jean-Philippe Chippaux, Natalia Bronzatto Medolago, Carlos Antonio Caramori, Ariane Gomes Paixão, João Paulo Vasconcelos Poli, Mônica Bannwart Mendes, Lucilene Delazari dos Santos, Rui Seabra Ferreira Jr and Benedito Barraviera

    Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:14

    Published on: 16 March 2017

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