Table 4 Symptoms in mice induced by intravenous administration of the aqueous extract of M. alcicornis
Dose (μg protein/g) | Symptoms | Death time |
|---|---|---|
Control | Normal behavior | No death |
1.5–3 | Little change, affected but calm, progressive malaise, and burning | No death |
6–12 | Progressive agitation, respiratory difficulty, despair, malaise, later slowness, muscle paralysis of the hind leg, respiratory failure, convulsions and death; intestinal inflammation, uremia, hemolysis in the eyes and nails | Mainly within 10 h |
24–48 | Respiratory difficulty, hypoactivity, paralysis of the hind leg, intestinal inflammation, uremia, redness of eyes and nails, respiratory failure, convulsions, and death | Mainly within 3 h |