Fig. 6

Involvement of cytokines on MT-II-induced articular hyperalgesia. MT-II (10 μg/joint) or PBS (vehicle) was injected in tibio-tarsal articulation (25 μL). Pain threshold was determined using a modified electronic pressure-meter test 8 h after MT-II injection, and represented as force (in g). a anti-TNFα antibody (0.5 μg/joint) or (b) anti-IL-1β antibody (1.5 μg/joint) or (c) anti-IL-6 antibody (4.0 μg/joint) or (d) anti-CINC-1 antibody (5.0 μg/joint) was injected 30 min before MT-II. Each point represents the mean ± SEM of six animals. *** p < 0.001 indicate statistically significant differences when compared with control group (vehicle + vehicle). ### p < 0.001 indicate statistically significant differences when compared with MT-II group (MT-II + vehicle)