Table 1 Antiparasitic activity and mammalian cytotoxicity of sertraline
From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
T. cruzi IC50 μM (±SD) | CC50 μM (±SD) | ||||||
|---|---|---|---|---|---|---|---|
Drugs | Trypomastigote (Y) | Trypomastigote BT (Y) | Amastigote L929 (Tulahuen) | Amastigote CC (Y) | Amastigote MØ (Y) | L929 | CC |
SERT | 1.8 ± 0.8 | 14.2 ± 5.5 | 10.0 ± 1.7 | 6.6 ± 1.4 | 1.4 ± 0.6 | 11.5 ± 2.4 | 25.0 ± 13.2 |
BZ | 17.7 ± 1.9 | 11.5 ± 1.0 | 2.5 ± 0.9 | 3.6 ± 1.0 | 5.0 ± 1.5 | 190.6 ± 13.4 | > 200 |