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Table 1 Antiparasitic activity and mammalian cytotoxicity of sertraline

From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

T. cruzi IC50 μM (±SD) CC50 μM (±SD)
Drugs Trypomastigote (Y) Trypomastigote BT (Y) Amastigote L929 (Tulahuen) Amastigote CC (Y) Amastigote MØ (Y) L929 CC
SERT 1.8 ± 0.8 14.2 ± 5.5 10.0 ± 1.7 6.6 ± 1.4 1.4 ± 0.6 11.5 ± 2.4 25.0 ± 13.2
BZ 17.7 ± 1.9 11.5 ± 1.0 2.5 ± 0.9 3.6 ± 1.0 5.0 ± 1.5 190.6 ± 13.4 >  200
  1. IC50 50% inhibitory concentration, CC50 50% cytotoxic concentration, CC cardiac cells, SERT sertraline, BZ benznidazole, SD standard deviation, BT bloodstream, peritoneal macrophage