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Table 1 Yields and major conditions for reactions shown in Scheme 1

From: Second-generation pterocarpanquinones: synthesis and antileishmanial activity

Entry

Heat

Cond. a

2 (%)

1

A

2a (20%)

2

MW b

A

2a (31%)

3

B

2a (57%)

4

MW b

B

2a (50%)

5

C

2a (65%)

6

D

2e (47%)

7

D

2e (46%)

  1. a Conditions: A – Pd(OAc)2 (10 mol%), Ag2CO3 (1.5 equiv.), acetone, reflux, 18 h; B - Pd(OAc)2 (10 mol%), Ag2CO3 (1.5 equiv.), pinacolone, reflux, 18 h; C - Pd(OAc)2 (10 mol%), Ag2CO3 (1.1 equiv.), PEG-400, 140 °C, 10 min.; D - Pd(OAc)2 (10 mol%), Ag2CO3 (1.1 equiv.), PEG-400, 90 °C, 10 min
  2. b MW: 40 W, 60 °C (acetone) or 110 °C (pinacolone), 40 min