Phyllomedusa bicolor skin secretion and the Kambô ritual
© den Brave et al.; licensee BioMed Central Ltd. 2014
Received: 28 May 2014
Accepted: 27 August 2014
Published: 2 September 2014
The ritual of Kambô or Sapo is a type of voluntary envenomation. During this purification ritual a shaman healer, from various South American countries, deliberately burns the right shoulder with a glowing stick from a fireplace. Excretions of Phyllomedusa bicolor (or Giant Leaf Frog, Kambô or Sapo) are then applied to these fresh wounds. This ritual is used as a means of purification of the body, supposedly brings luck to hunters, increases stamina and enhances physical and sexual strength. All the peripheral and most of the central effects of the secretion can be ascribed to the exceptionally high content of active peptides, easily absorbed through burned skin. This article describes the ritual and the bio-active peptides from the secretion.
Dear Editor of JVATiTD
Kambô or Sapo is a purification ritual performed in numerous South American countries including Bolivia, Brazil, Colombia, Peru, French Guiana, Suriname and Venezuela. During the ceremony, a shaman healer deliberately burns the right shoulder of the participant with a burning stick from a fireplace. Subsequently, secretion of Phyllomedusa bicolor (giant leaf frog or kambô) is applied to the fresh wounds. The aim of this ritual is the purification of the body. All the peripheral and most of the central effects of the secretion can be ascribed to its exceptionally high content of active peptides easily absorbed through wounded skin .
The word sapo means frog in Portuguese and Spanish, whereas kambô is the common name of Phyllomedusa bicolor in South America. The frogs are found in the rainforests of Bolivia, Brazil, Colombia, Peru, French Guiana, Suriname and Venezuela near streams. To collect the secretion, the shaman carefully ties the frog by each leg into an X shape, next to an open fire. The secretion is carefully scraped off the skin, and left to dry on small sticks for storage. From these sticks, it will be applied to the burns. After this, the frog is released and returns to its natural habitat. The frog is never harmed, but always treated with utmost care and respect as the indigenous tribes believe that to harm it will anger the animal spirits.
All the peripheral and most of the central effects of the secretion – including tachycardia, dizziness, nausea, vomiting and sedation – are provoked by the high content of active peptides. These peptides include phyllocaerulein (hypotensive neuropeptide), phyllomedusin (a tachykinin which excite neurons, evokes behavioral responses, contracts smooth muscles and is a potent vasodilator and secretagogue), phyllokinin (induces relaxation of arterial smooth muscle by targeting bradykinin receptors), dermorphins (opiate-like activity) and deltorphins (opiate-like activity) .
The dried secretions of Phyllomedusa bicolor on wooden sticks are commercially available as “Kambô sticks” and are sold on markets and on the internet. Therefore, we want to inform doctors worldwide about the ritual of Kambô or Sapo as it is a type of voluntary envenomation. The ritual has no proven beneficial effects and no known influence on the long-term health of the person, but caution is required due to the toxicological aspects of the bioactive peptides and the possibility of infection of the wounds.
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