Table 3 Pharmmapper results
From: 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Target | PDB Code | Ligand Compounds | Max z’score valuea | Function |
|---|---|---|---|---|
S-Methyl-5-thioadenosine phosphorylase | 1CG6 | All derivatives | 3.69 | Nucleotide transport and metabolism |
Adenosine deaminase | 1 V79/1 V89 | All but compound 3 | 4.72 | Nucleotide transport and metabolism |
UvrABC System Protein B | 1C40 | All but compound 4 | 3.59 | Replication, recombination, and repair |
Dihydrofolate reductase | 1IA2 | All but compound 4 | 3.12 | Coenzyme transport and metabolism |
Queuine t-RNA-ribosyltransferase | 1Q66 | All but compounds 3 and 4 | 3.02 | Translation, ribosomal structure and biogenesis |